National Oceanic and Atmospheric Administration (NOAA Fisheries) - Endangered Species Act (ESA) jurisdiction over anadromous fish; also has a role in regulating ocean fisheries. 

U.S. Fish and Wildlife Service (USFWS) – ESA jurisdiction over plants, wildlife, and resident fish; also operates and administers hatchery programs and national wildlife refuges.

Bonneville Power Administration (BPA) - markets electricity from federal dams; also has a key role funding fish and wildlife mitigation.

U.S. Army Corps of Engineers (USACE) – operates federal dams and navigation locks for multiple uses.

U.S. Bureau of Reclamation (Reclamation) – operates federal dams for multiple purposes, including irrigated agriculture and hydroelectric power. 

Environmental Protection Agency (EPA) – implements and enforces the Clean Water Act.

U.S. Forest Service (USFS) – manages over 50% of available spawning and rearing habitat for salmon and steelhead within the basin.   Other priority management objectives for the agency include: wilderness, vegetation management, wildland fire suppression, grazing, and recreation.

Bureau of Land Management (BLM) - manages about 10 percent of the available spawning and rearing habitat for salmon and steelhead within the basin.  Other management of their federal lands include; wildlife, recreation, timber harvest, mineral extraction and other public uses.

Bureau of Indian Affairs (BIA) - provides services to Indians, Indian tribes and Alaska Natives. The Northwest region incorporates Oregon, Washington, Idaho, Montana and southeastern Alaska. 

U.S. Geological Survey (USGS) - A multi-disciplinary science organization that focuses on biology, geography, geology, geospatial information, and water.

Natural Resources Conservation Service (NRCS) (non-signatory member) – works with landowners through conservation planning and assistance to benefit the soil, water, air, plants, and animals for productive lands and healthy ecosystems.